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The original version of this article incorrectly stated that Lea Davis is organizing a study to look for genetic variants linked to gender dysphoria. We have corrected the article to reflect the fact that Davis is focused on understanding the genetic contribution to gender identity, not specifically gender dysphoria. Techniques such as functional MRI have begun to yield clues to possible biological underpinnings of gender. It is one of the pivotal points in biology, and the biology of humans.

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Only a handful of studies have addressed the question of how these hormone treatments affect the brain. The original version of this article incorrectly stated that Lea Davis is organizing a study to look for genetic variants linked to gender dysphoria. Also still to be determined, adds Savic, is whether the brain differences that have been identified between cis and trans people persist after hormone treatment. Yet a biological understanding of the contrast between the natal sex and the gender identity of transgender people remains elusive. A Dutch study similarly concluded that the overall brain volumes of transgender women dropped as a result of treatment, while those of transgender men increased, particularly in the hypothalamus Eur J Endocrinol , Other studies have pinpointed characteristics of the transgender brain that fall in between what is typical for either sex—results that proponents of the developmental mismatch hypothesis generally see as support for their idea.

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It is typically difficult to recruit enough transgender subjects to conduct studies with high statistical power. Zubiaurre-Elorza et al. One prominent hypothesis on the basis of gender dysphoria is that sexual differentiation of the genitals occurs separately from sexual differentiation of the brain in utero, making it possible that the body can veer in one direction and the mind in another. Yet a biological understanding of the contrast between the natal sex and the gender identity of transgender people remains elusive. But some groups are specifically exploring the effects that these treatments might have on the brain. Dick Swaab of the Netherlands Institute for Neuroscience is a pioneer in the neuroscience underlying gender identity.

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Description: Only a handful of studies have addressed the question of how these hormone treatments affect the brain. Every music video needs a leading lady, and these stars didn't come cheap. Savic says she hopes the results of studies on transgender people will help make gender identity a less-charged issue. And last year, Karolinska Institute neuroscientist Ivanka Savic found that the brains of transgender men taking testosterone showed several changes, including increases in connectivity between the temporoparietal junction involved in own-body perception and other brain areas Cereb Cortex , doi. Functional similarities between transgender people and their cisgender counterparts were apparent in a study led by Julie Bakker of VU University Medical Center and the Netherlands Institute for Neuroscience in Amsterdam that examined neural activity during a spatial-reasoning task. Animal studies demonstrated that the genitals and the brain acquire masculine or feminine traits at different stages of development in utero, setting up the potential for hormone fluctuations or other factors to put those organs on different tracks. In the mids, his group examined the postmortem brains of six transgender women and reported that the size of the central subdivision of the bed nucleus of the stria terminalis BSTc or BNSTc , a sexually dimorphic area in the forebrain known to be important to sexual behavior, was closer to that of cisgender women than cisgender men. For now, as is the case for many aspects of human experience, the neural mechanisms underlying gender remain largely mysterious. Some studies have pinpointed characteristics of the transgender brain that fall in between what is typical for either sex. Moreover, he notes, the changes in the cerebellum were linked to treatment duration.
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